Obesity is a major epidemic that affects millions of people globally. Obesity also has a substantial impact on a woman’s ability to carry a full-term pregnancy. Call and book your appointment with Dr. Chandana Lakkireddi who is the Best IVF doctor in Hyderabad.
Obesity is defined by a very high Body Mass Index (BMI), which is a reflection of body fat content. According to polls and research, one in every four women is overweight. The rates are higher among women who are having difficulty conceiving.
Infertility, along with various other sexual health issues associated with obesity, is a significant one, contributing to the troubling trend of the need for and failure of assisted reproductive treatments for conception.
Obesity is linked to infertility.
The association between obesity and infertility is one of the most well-established links between obesity and reproductive disorders. Obesity reduces the likelihood of a successful pregnancy during spontaneous conception cycles.
Obesity may reduce the odds of pregnancy in women who are undergoing reproductive therapy by speeding and enhancing their ovulation cycles for higher chances of conception.
High amounts of leptin and low levels of adiponectin may also lower conception rates. If weight loss is achieved, fertility can be partially recovered.
Obesity and infertility
Obesity is likely to create insulin resistance, which has been associated to anovulation, or a woman’s failure to generate an egg from each ovary each month. Obesity and insulin levels both result in altered sex hormones, high androgens (male hormones), and high amounts of free growth factor 1.
According to studies, anovulation-related infertility is 30% more common in women with BMIs ranging from 24 to 31 than in women of normal weight. Furthermore, people with a BMI greater than 31 have a 170 percent greater likelihood.
Only a 5% reduction in body weight can boost ovulation rates and decrease biochemical abnormalities.
According to research, the underlying cause of anovulation in obese women is most likely polycystic ovarian syndrome (PCOS). PCOS is linked to obesity or overweight, as well as symptoms of excess male hormone secretion such as hairiness, acne, high cholesterol, and insulin resistance.
Obesity and pregnancies
Obesity causes common pregnancy issues such as preeclampsia or, in severe cases, eclampsia, or pregnancy-induced high blood pressure.
Diabetes during pregnancy, commonly known as gestational diabetes, is caused by obesity and related insulin resistance. Schedule your appointment with Best infertility treatment in hyderabad.
Miscarriage and obesity
Obesity increases the risk of miscarriage and, as a result, lowers the likelihood of a successful pregnancy in obese women. This could be attributed to a variety of factors, including:
Eggs or ovum of poor quality
Insulin resistance causes defective implantation or reception of the fertilised egg into the womb.
Hormone deficiencies and changes that aid in pregnancy maintenance
Obesity and failure of assisted reproductive technology
Obesity is responsible for a high failure rate of successful pregnancy, even when artificial means such as ovulation stimulation and assisted conception are used.
According to the Fertility Society, “women who are obese must begin a weight loss programme, and those who are seriously overweight (characterised as having a BMI of 36 or higher) should not get treatment until their weight has been reduced.”
Hormones and obesity
Obesity reduces testosterone, follicle stimulating hormone, inhibin B, and sex hormone binding globulin levels. Obese men have decreased sperm count and quality as a result of this.
Obese women have increased androgen metabolism as well as enhanced oestrogen levels. Obese males have low oestrogen and testosterone levels.
Obesity has a significant and undeniable negative impact on fertility and pregnancy outcomes. The maternal height and weight measurements are used to determine the body mass index (BMI) in kg/m2. Obesity is defined as having a BMI greater than 30 and morbid obesity as having a BMI greater than 40. Anovulation and infertility are common in obese women with extra adipose tissue due to aberrant hypothalamus and pituitary hormone releases.
In women, obesity is significantly linked to polycystic ovarian syndrome (PCOS). Obese women are also more prone to diabetes and insulin resistance. Women with PCOS and/or obesity frequently have irregular menstrual cycles and are infertile because they do not ovulate. Most women with PCOS and/or obesity have an endocrine imbalance known as “insulin resistance,” in which the body does not process insulin appropriately, according to researchers.
Women with insulin resistance may have normal blood glucose levels, but because their cells are resistant to insulin, the body overcompensates by creating even greater quantities of insulin to maintain normal blood glucose levels. Higher insulin levels result in greater fat accumulation (obesity) as well as disruption of appropriate ovarian hormone production (increased male hormone), limiting ovulation. Obesity has a negative impact on pregnancy rates even when fertility medicines or in vitro fertilisation (IVF) therapies are used.
Normal ovarian function (ovulation and normal female hormone production) often recovers when obese women correct their insulin resistance with good food, exercise, vitamins (Inositol), and/or insulin-sensitizing medicines such as metformin (Glucophage). Metformin, Inositol, regular exercise, and/or weight loss of 5-10% of body weight can all lead to spontaneous pregnancies, but they can also greatly enhance pregnancy rates with any fertility treatments. There are fewer pregnancy problems and improved perinatal outcomes.
Obesity rates are rising, and many individuals are aware that being overweight can have a severe impact on one’s overall health. Being overweight or obese as a male might also make conceiving more difficult for a couple. In fact, men who weigh 20 pounds over than their optimal weight are 10% more likely to be infertile.
The link between obesity and male infertility is undeniable, but why is this so?
The greater a man’s BMI, the more probable he is to have a low sperm count. He is also more prone to poor sperm quality and mobility. These conditions can make it more difficult to conceive, and poor sperm quality can result in miscarriage.
Obesity or being overweight might cause hormonal abnormalities. When a man’s body is overweight, the male hormone testosterone converts to the female hormone oestrogen. When a man’s oestrogen levels are greater than normal, his testicles are less likely to generate sperm.
Another issue with fat guys is that the scrotum is frequently in close contact with the body. Being closer to the surrounding body tissues raises the temperature of the scrotum, keeping the sperm warm. The sperm may be harmed as a result of the greater temperature.
Taking the necessary actions to get a healthy body weight
Doctors frequently urge weight loss to promote fertility due to the association between obesity and male infertility. Patients who reduce weight by consuming a nutritious diet and exercising have a better chance of conceiving. In reality, after the man’s BMI is reduced from an unhealthy level, many couples can conceive relatively rapidly. This likewise applies to the female companion.
If a couple continues to struggle to conceive after losing weight, doctors will employ diagnostic testing to develop a tailored fertility treatment plan. Depending on the circumstances of the marriage, treatment may include intrauterine insemination (IUI), in vitro fertilisation (IVF), or intracytoplasmic sperm injection (ICSI).
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